Sulfasalazine, sold under brand names Azulfidine, Salazopyrin, Sulazine and others, is a 'first line' prescription drug used to treat Rheumatoid Arthritisplugin-autotooltip__plain plugin-autotooltip_bigRheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic severe inflammatory disease believed to affect around 1% of the global population. It primarily affects joints,which typically become warm, swollen and painful. Pain and stiffness often worsen following rest. Most commonly, the wrists and hands are involved, with the same joints typically involved on both sides of the body., Ulcerative colitisplugin-autotooltip__plain plugin-autotooltip_bigUlcerative colitis

"Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary symptoms of active disease are abdominal pain and diarrhoea mixed with blood. Weight loss, fever, and anaemia may also occur. and Crohn's diseaseplugin-autotooltip__plain plugin-autotooltip_bigCrohn's disease

Crohn's disease is a type of inflammatory bowel disease (IBD) that can affect any part of the entire digestive tract. It causes inflammation and in severe cases, ulcers can form. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss.. It was first approved for use in the US in 1950.

Despite more than 70 years of general use, and extensive research, the 'mechanism of action' of the drug - either for rheumatoid arthritis, ulcerative colitis or Crohn's - is unknown.

Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it works. One proposed mechanism is the inhibition of prostaglandins, resulting in local anti-inflammatory effects in the colon.

Source : Wikipedia