Amantadine was originally developed in the mid 1960s as an anti-viral drug used to treat Influenza-A. Now largely withdrawn for use against 'flu due to widespread drug-resistance concerns.
It was subsequently found to be of use in treating the dyskinesia (faulty movements) and rigidity of. It's now sold under the brand names Gocovri, Wiregyt, Amanta, Amixx, Inflex, Tregor and others, and often used alongside other drugs such as Levodopa.
The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Source : Pubmed
Ideas for new topics, and suggested additions / corrections for old ones, are always welcome.
If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !
Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.
( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)
You are currently viewing an auto-translated version of Wikenigma
Please be aware that no automatic translation engines are 100% accurate, and so the auto-translated content will very probably feature errors and omissions.
Nevertheless, Wikenigma hopes that the translated content will help to attract a wider global audience.