Since the 1960s, electrical heart defibrillators have been routinely used as a treatment for life-threatening cardiac dysrhythmias, especially ventricular fibrillation. The exact mechanism of action is yet to be determined, but is presumably linked to large-scale electrical depolarization of the heart muscle.
The exact mechanism of defibrillation is not well understood. One theory is that successful defibrillation affects a critical mass of the heart, resulting in insufficient remaining heart muscle to continue the arrhythmia. Recent mathematical models of defibrillation are providing new insight into how cardiac tissue responds to a strong electrical shock.“
Source : Wikipedia
Editor's note: This is a quite rare example of a modern man-made technological system which clearly works, but that no-one as yet understands. Also see : and
(Note there are many examples of man-made medicines which work in as-yet-unexplained ways - see the medicine / drugs section for examples.)
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