A proportion of adults are (or claim to be) 'immune' from developing hangovers after heavy alcohol consumption.

The underlying biochemical process(es) that may exempt some drinkers from hangovers is currently unknown.

In addition, estimates vary widely as to the prevalence of 'hangover resistance'.

A 2008 study (Curr Drug Abuse Rev. 1(1):42-6) from the US put the figure at around 23 percent.

A 2017 study (Addict Behav Rep. 9;5:14-18) from Canada put the figure at around 5 percent.

Also see : Alcohol intoxicationplugin-autotooltip__plain plugin-autotooltip_bigAlcohol intoxication

"Despite the fact that alcohol has been used and misused for hundreds of years, the mechanism of action of this simple molecule remains the subject of study. Alcohol use results in diverse behavioral effects, including intoxication, cognitive impairment, motor incoordination, tolerance and dependence, and these effects are likely due to its actions on multiple brain proteins. and Hangoverplugin-autotooltip__plain plugin-autotooltip_bigHangover

Despite its ubiquity and history spanning several thousand years, the understanding of alcohol-induced 'Hangover' is limited.

"Alcohol hangover is characterized by adverse physical and mental effects that occur the next morning after the intake of toxic doses of alcohol. This phenomenon is a very frequent experience among alcohol-consuming people and it has been associated to high socio-economic costs, mainly due to absenteeism and poor performance in academic and work settings. Mult…