Obsessiveâ€“compulsive disorder (OCD) is a mental condition in which a person feels the need to perform certain routines repeatedly (called â€ścompulsionsâ€ť), or has certain thoughts repeatedly (called â€śobsessionsâ€ť). The sufferer is unable to control either the thoughts or activities for more than a short period of time.
The cause of the disorder has not yet been established.
Data [â€¦] suggests that three brain areas are involved with OCD: the orbitofrontal cortex (OFC), the anterior cingulate cortex (ACC), and the head of the caudate nucleus. Several studies have found that in patients with OCD, these areas: (1) are hyperactive at rest relative to healthy control; (2) become increasingly active with symptom provocation; and (3) no longer exhibit hyperactivity following successful treatment with SRI pharmacotherapy or cognitive-based therapy. This understanding is frequently cited as evidence that abnormality in these neuroanatomical regions may cause OCD.
Source : Wikipedia
Note that the current first-line treatment for managing the disorder is usually the prescription of SSRI drugs - notably ref.)(Prozac), which, to date, has not has its 'mechanism of action' fully explained. And, unfortunately, only a small percentage of people with OCD are significantly responsive to SSRI treatment (
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