Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome [PFAPA] is a medical condition, typically starting in young children, in which high fever occurs periodically at intervals of about 3â€“5 weeks, frequently accompanied by aphthous-like ulcers, pharyngitis and/or cervical adenitis (cervical lymphadenopathy). The syndrome was described in 1987 and named two years later.â€ś
Source : Wikipedia
PFAPA is the most common periodic fever syndrome in children, but its cause(s) and its pathogenesis are currently unknown. Suggested possible causes include problematic genetics and/or effects of previous infections.
Research from 2020 suggests thatmay be on a 'common spectrum' along with PFAPA - and both could be different manifestations of the same 'spectrum disorder'.
See: Common genetic susceptibility loci link PFAPA syndrome, BehĂ§etâ€™s disease, and recurrent aphthous stomatitis PNAS, 117 (25) 14405-14411
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