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Kyrle disease

Kyrle disease is a relatively rare 'perforating' skin condition which leads to the formation of multiple large (up to 1.5cm) skin papules that have central keratin plugs. It usually affects the legs, but can also erupt in other areas. It was first described in 1916. The cause is currently unknown.

The disease is 'associated' with Diabetes (type 1)plugin-autotooltip__plain plugin-autotooltip_bigDiabetes (type 1)

Type 1 Diabetes is a chronic autoimmune disease that occurs either when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces. Insulin is a crucial hormone required for the body to regulate and use blood sugar.
, liver disease, and especially with kidney disease. The prevalence in kidney dialysis patients being around 10%.

The exact etiology of Kyrle disease is unknown. Many theories have been proposed in the literature including infectious, abnormal keratinization, defective differentiation of the epidermis and dermo-epidermal junction, elevated serum and tissue concentrations of fibronectin, uremia (renal failure), and hyperphosphatemia (diabetes mellitus). The high incidence of systemic disease associated with the development of Kyrle disease suggests an underlying systemic disorder as the main etiology.

Source : Europe PMC, StatPearls

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