Random article ( of 1126 ) Latest updates

User Tools

Site Tools


content / medicine / diseases / g-l / huntington_disease

Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown

Huntington's disease

Huntington disease is an inherited, progressive, incurable neurodegenerative disorder that primarily affects cells in the brain.

The genetic components which trigger Huntington's disease were discovered in the 1990's. Sufferers have a mutation in the Huntingtin gene (HTT). The gene controls the production of the protein Huntingtin, which is known to interact with over 100 other proteins. It is thought to have multiple functions.

However :

Although the genetic basis for this condition has been known for nearly 30 years, how this causes disease is still unresolved. Of late there has been increasing evidence suggesting that dysfunction in macroautophagic/autophagic pathways may contribute to cellular dysfunction and death.

Source : Autophagy Volume 18, Issue 9 (2022)
THIS WEBSITE DOES NOT USE TRACKING, ADVERTISING, OR ANALYTICAL COOKIES OF ANY KIND.
All essential cookies (for login status etc) are automatically deleted at the end of the session.
(full details here)

Show another (random) article

Suggestions for corrections and ideas for articles are welcomed : Get in touch!


Further resources :