User Tools

    To create and edit articles, please register and log-in

Main Menu : categories & index etc.

Main menu
Click categories to expand

A-Z listingplugin-autotooltip__plain plugin-autotooltip_bigA-Z listing

This is an alphabetical index of all content pages.

Other categories



Also see

Importance Ratings
Curator's rationale
AI Policy

Twitter feed 𝕏

Feeds + s.e.o. etc.
rss / xml feed
sitemap file
A-Z listing (archived)

Indexed under : Medicine / Diseases / A - F

Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown

Castleman disease

Casleman Disease is a condition which leads to lymph node enlargements and dysfunction. It was first described in 1956, and since then three types have been identified :

• Unicentric Castleman disease (UCD)
• Idiopathic multicentric Castleman disease (iMCD)
• Human herpesvirus 8 associated multicentric Castleman disease (HHV-8-associated MCD).

The cause or causes of the first two types are unknown, although it's presumed to be an auto-immune problem. The third type is associated with infections of the human herpes-virus 8 (HHV-8) and in the vast majority of cases do not lead to any disease. It's estimated that 10 - 40% of people worldwide are permanently infected, but their immune system suppresses any symptoms. The reason why the virus initiates Castleman in some individuals is unknown.

Note: The prevalence of the disease (outside the US, where there are more than 6,000 cases per year) is also unknown.

More info : The Castleman Disease Collaborative Network

    Please share this page to help promote Wikenigma !

Dear reader : Do you have any suggestions for the site's content?

Ideas for new topics, and suggested additions / corrections for older ones, are always welcome.

If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !

Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.

( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)

Automatic Translation

You are currently viewing an auto-translated version of Wikenigma

Please be aware that no automatic translation engines are 100% accurate, and so the auto-translated content will very probably feature errors and omissions.

Nevertheless, Wikenigma hopes that the translated content will help to attract a wider global audience.

Show another (random) article

Further resources :