====== Gemfibrozil ====== Gemfibrozil - sold under brand name of //Lopid//, //Je//zil and others - is used to treat abnormal blood lipid levels. Currently around 4 million prescriptions per year in the US alone. Its mechanism of action is, to date, unknown. >The exact mechanism of action of gemfibrozil is unknown; however, several theories exist regarding the very low density lipoprotein (VLDL) effect; it can inhibit lipolysis and decrease subsequent hepatic fatty acid uptake as well as inhibit hepatic secretion of VLDL; together these actions decrease serum VLDL levels and increase HDL-cholesterol; the mechanism behind HDL elevation is currently unknown. >\\ Source [[https://en.wikipedia.org/wiki/Gemfibrozil|Wikipedia]]