====== Non-celiac gluten sensitivity (NCGS) ======

Non-celiac gluten sensitivity (NCGS) is currently defined as :// "a clinical entity induced by the ingestion of gluten leading to intestinal and/or extraintestinal symptoms that improve once the gluten-containing foodstuff is removed from the diet, and celiac disease and wheat allergy have been excluded".//<sup>[ ref. needed ]</sup>

It was first described in 1976. Some studies estimate it to be the most common form of the gluten-related disorders - with incidence rates of up to 13% of the (Western) population.

The cause is unknown - though there is speculation that it's an immune-system malfunction of some kind. Some research groups maintain that there is not enough evidence to class NCGS as a distinct clinical disorder.

>Currently there is an absence of any reliable biomarkers, therefore, NCGS remains a diagnosis of exclusion."\\ \\ See : [[https://onlinelibrary.wiley.com/doi/10.1111/apt.13155|Systematic review: noncoeliac gluten sensitivity]]  //Alimentary Pharmacology & Therapeutics//,  Volume 41, Issue 9 p. 807-820 {{:oa_padlock_grn.png?16&nolink|Open Access}}

//Note ://  Recent research is suggesting that a significant proportion <sup>[ how much? ] </sup>of those diagnosed with NCGS and IBS are in fact suffering from an intolerance to //Fructan// - a polymerised version of the sugar //Fructose -// which is found in all of the wheat family and many other foods. Fructan intolerance can be substantially relieved by adding a powdered enzyme to food. Fructan intolerance (FI) also remains unexplained.

Example ref. [[https://link.springer.com/chapter/10.1007/978-3-030-56722-4_18|Diagnosis and Management of Gluten-Associated Disorders ]]{{:oa_padlock_red.png?16}}<sup>[ paywalled ]</sup>

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Also see : [[content:medicine:diseases:g-l:ibs]]