====== Migraine ======

>Chronic migraine has a great detrimental influence on a patient’s life, with a severe impact on socioeconomic functioning and quality of life. Chronic migraine affects 1–2% of the general population, and about 8% of patients with migraine; it usually develops from episodic migraine at an annual conversion rate of about 3%."

However, despite many decades of intensive research :

>__"The physiological mechanisms that underlie development of chronic migraine are not entirely understood."__ \\ \\  Source :  [[http://www.nature.com/nrneurol/journal/v12/n8/full/nrneurol.2016.93.html|Chronic migraine: risk factors, mechanisms and treatment]] //Nature Reviews Neurology// 12, 455–464 (2016)

Or as the [[https://en.wikipedia.org/wiki/Migraine#Cause|Wikipedia]] page more directly puts it : //"The underlying causes of migraines are unknown."//

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//Note :// Many of the first-line 'Western medicine' drugs routinely used to treat migraine work by as-yet-unknown mechanisms, e,g, [[content:medicine:drugs:amitriptyline]], [[content:medicine:drugs:lacosamide]],[[content:medicine:drugs:triptan]] ,[[content:medicine:drugs:valproate]]etc.

~~stars>3/5~~