====== Huntington's disease ======

//Huntington disease //is an inherited, progressive, incurable neurodegenerative disorder that primarily affects cells in the brain.

The genetic components which trigger Huntington's disease were discovered in the 1990's. Sufferers have a mutation in the //Huntingtin gene// (HTT). The gene controls the production of the protein //Huntingtin,// which is known to interact with over 100 other proteins. It is thought to have multiple functions.

However :

>__Although the genetic basis for this condition has been known for nearly 30 years, how this causes disease is still unresolved.__ Of late there has been increasing evidence suggesting that dysfunction in macroautophagic/autophagic pathways may contribute to cellular dysfunction and death.\\ \\ Source : [[https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2069438|Autophagy]]  Volume 18, Issue 9 (2022)